2024 Shoc2 molecular weight

Shoc2 molecular weight

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August undefined, 2024

Web20 Dec 2012 · Clathrin-independent endocytosis includes internalization via caveolae or various small molecular weight GTP binding proteins (i.e., Arf6, RhoA, CDC42) ... Both the loss of Shoc2 (by RNAi) and certain mutants of Shoc2 that lead to membrane targeting result in decreased ERK1/2 activity . These data provide strong evidence that Shoc2 is a … Web5 Nov 2024 · We reveal that, in the Shoc2 module, USP7 functions as a molecular ‘switch’ that controls the E3 ligase HUWE1 and the HUWE1-induced regulatory feedback loop. We also demonstrate that disruption of Shoc2-USP7 binding leads to aberrant activation of the Shoc2-ERK1/2 axis.

Entry - *602775 - SHOC2 LEUCINE-RICH REPEAT SCAFFOLD PROTEIN; SHOC2 …

Web17 Dec 2024 · SHOC2 leucine rich repeat scaffold protein (SHOC2) has been identified as a positive regulator of the Ras pathway; however, the function of SHOC2 in breast cancer has rarely been explored. The current study investigated the effects of SHOC2 on breast cancer cell growth and evaluated its prognostic value in patients with breast cancer. The effects … Web16 Apr 2014 · One is a 24 Mb duplication of 12q24.1-24.3 containing PTPN11 and the other is a 183 kb deletion of 10q25.2 including SHOC2. The SNP-array results were further validated by quantitative PCR (qPCR). This is might be the first report suggesting that haploinsufficiency of SHOC2 can result in a RASopathy-like phenotype. dogfish tackle \u0026 marine

The scaffold protein Shoc2 controls ERK1/2‐driven neural crest ...

Web4 May 2024 · Significantly, SHOC2 inactivation is tolerated well in the short term as mice appear normal up to ~10 weeks post-treatment. However, at later times KO female mice … WebSulahian, Kwon, and Walsh et al. performed several loss-of-function CRISPR-Cas9 screens in KRAS-mutant cancer cells treated with a MEK inhibitor and define the landscape of modifiers of MEK inhibitor sensitivity while highlighting that SHOC2 is a potent synthetic lethal target that serves as a critical signaling node to mediate MAP kinase pathway reactivation upon … Web8 Jul 2024 · The authors identified a heterozygous mutation (S2G; 602775.0001) in the SHOC2 gene in 4 unrelated individuals. They then analyzed the SHOC2 gene in a cohort of … dog face on pajama bottoms

SHOC2–MRAS–PP1 complex positively regulates RAF activity and …

Web29 Sep 2024 · Here we present a cryo-electron microscopy structure of the SHOC2–PP1C–MRAS complex to an overall resolution of 3 Å, revealing a tripartite molecular architecture in which a crescent-shaped ... Web29 Sep 2024 · Total Structure Weight: 127.02 kDa ; Atom Count: 7,729 ; Modelled Residue Count: 965 ; Deposited Residue Count: 1,120 ; Unique protein chains: 3 dog face jackeWeb1 Oct 2014 · HUWE1 mediates ubiquitination and, consequently, the levels of Shoc2. Additionally, we show that both Shoc2 and HUWE1 are necessary to control the levels and ubiquitination of the Shoc2 signaling partner, RAF-1. Depletion of HUWE1 abolishes RAF-1 ubiquitination, with corresponding changes in ERK1/2 pathway activity occurring. dog face mask skincare

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Shoc2 molecular weight

The amplitude of SHOC2-mediated ERK1/2 signals has been proposed to be regulated by differential regulation of RAF activation at the plasma membrane and internalized endosome compartment (PMID 31213532) as well an alternative model proposing post-translational modifications(PMID 25022756). SHOC2 ubiquitination mediated by HUWE1 is triggered by growth factor activation of the ERK1/2 pathway and is a prerequisite for the subsequent ubiquitination o… Web26 Mar 2024 · Our findings expand the molecular spectrum of pathogenic SHOC2 variants, provide a more accurate picture of the phenotypic expression associated with variants in this gene, and definitively ...

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Web7 Nov 2013 · SHOC2 is mutated in Noonan syndrome and plays a key role in the activation of the ERK-MAPK pathway, which is upregulated in the majority of human cancers. SHOC2 functions as a PP1-regulatory protein and as an effector of MRAS. Here we show that SHOC2 and MRAS form a complex with SCRIB, a polarity protein with tumor suppressor … Web18 Jun 2024 · To study a molecular mechanism for this selective SHOC2 contribution to 3D growth, lysates of parental and SHOC2 KO DLD-1 cells growing in 2D or suspension (poly-HEMA–coated dishes) were compared. In suspension cells, phosphorylation of AKT and its downstream substrate site S1718 AF6 is strongly impaired ...

WebBiological assembly of SHOC2 protein as shown by crystal structure to a resolution of 2.4 Angstrom. Sulfate molecules are labeled purple. Structure from 10.2210/pdb7TVG/pdb. SHOC2 protein leucine rich domain. Leucine amino acids shown as bright orange sticks. Web4 May 2024 · SHOC2 inhibition lowers the concentration of MEK inhibitor required for cytotoxicity and drives tumor regressions in xenograft models. Biochemically, we show …

WebThe .gov means it’s official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site. Web8 Jul 2024 · 602775 - SHOC2 LEUCINE-RICH REPEAT SCAFFOLD PROTEIN; SHOC2 - SUPPRESSOR OF CLEAR, C. ELEGANS, HOMOLOG OF;; RAS-BINDING PROTEIN SUR8, C. ELEGANS, HOMOLOG OF; SUR8 - SHOC2 ... Molecular Genetics. Using a systems biology approach based on in silico protein network analysis that identified SHOC2 as a candidate …

Web21 Mar 2024 · Molecular mass: 64888 Da Protein existence level: PE1 Quaternary structure: Interacts with M-Ras/MRAS, and RAF1 (PubMed:16630891, 25137548). Forms a …

Web18 Jun 2024 · SHOC2 phosphatase complex-dependent and -independent mechanisms of RAF and ERK activation that are differentially ... dependent-mechanisms, which thus presents a therapeutic op-portunity. This study provides a molecular framework for how targeting the SHOC2-holophosphatase regulatory node of the RAF activation process … dogezilla tokenomicsWeb12 Dec 2013 · Introduction. RAS proteins (H-, N- and K-RAS) function as molecular switches, cycling between active GTP-bound and inactive GDP-bound states, and are mutated in ∼30% of human tumors (Malumbres and Barbacid, 2003).The best-characterized RAS effector pathway is the RAF→MEK→ERK kinase cascade, or ERK-MAPK pathway, which is an … dog face kaomojiWeb13 Jul 2024 · SHOC2 Ile173 (Met173 in WT SHOC2) fills a hydrophobic space produced by SWI, SWII and SHOC2 LRR domains. SHOC2 Gln269/His270 resides at the interface of all … doget sinja goricaWeb20 Jun 2001 · SHOC2 DMDM 14423936 ClinGen HGNC:15454 GenCC HGNC:15454 PTM/Processing Features Showing features for chain. Expand table Proteomic databases CPTAC CPTAC-1562 EPD Q9UQ13 MassIVE Q9UQ13 MaxQB Q9UQ13 PaxDb Q9UQ13 PeptideAtlas Q9UQ13 ProteomicsDB 85490 [ Q9UQ13-1] 85491 [ Q9UQ13-2] jPOST … dog face on pj'sWeb23 Aug 2024 · Our findings expand the molecular spectrum of pathogenic SHOC2 variants, provide a more accurate picture of the phenotypic expression associated with variants in … dog face emoji pngWeb21 Jun 2013 · Shoc2 is comprised of two main domains: the 21 leucine rich repeats (LRRs) core and the N-terminal non-LRR domain. We demonstrated that the N-terminal domain mediates Shoc2 binding to both M-Ras and Raf-1, while the C-terminal part of Shoc2 contains a late endosomal targeting motif. ... Molecular Modeling. A model of the Shoc2 … dog face makeupWeb14 Jul 2014 · Lanes MW, molecular weight markers (numbers to the left of the gels are in thousands). +6 HUWE1 regulates the ubiquitination of RAF-1 in a Shoc2-dependent manner. dog face jedi