Phosphopantetheine-binding protein
WebJul 21, 2024 · The phosphopantetheine-binding domain (PP-binding superfamily), conserved in ACP proteins, is the prosthetic group of ACP, which acts as a linker for the attachment of the activated FA and amino acid groups via a phosphodiester bond ( Crawford et al. 2008; Meier et al. 2010; Roujeinikova et al. 2002 ). WebAug 31, 2015 · In vitro experiments have shown that in addition to vitamin B5, pantetheine can also be phosphorylated by pantothenate kinase activity, and the formed product, 4′-phosphopantetheine, can serve as...
Phosphopantetheine-binding protein
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WebOct 5, 2001 · 4'-Phosphopantetheine transferases (PPTases) transfer the 4'-phosphopantetheine moiety of coenzyme A onto a conserved serine residue of acyl … WebPhosphopantetheine-binding protein (Pectobacterium carotovorum PC1) - STRING interaction network Nodes: Network nodes represent proteins splice isoforms or post …
WebJul 1, 2003 · Phosphopantetheine adenylyltransferase (PPAT) regulates the key penultimate step in the essential coenzyme A (CoA) biosynthetic pathway. PPAT catalyzes the reversible transfer of an adenylyl group from Mg2+:ATP to 4′-phosphopantetheine to form 3′-dephospho-CoA (dPCoA) and pyrophosphate. WebPhosphopantetheine-binding protein Imported. Gene names. ORF names. C4F17_18890 Imported. Organism names. Organism. Variovorax sp. PMC12 Imported. Taxonomic identifier. 2126319 NCBI. Taxonomic lineage. Bacteria > Proteobacteria > Betaproteobacteria > Burkholderiales > Comamonadaceae > Variovorax. ... Similar …
WebJan 8, 2024 · 4'-Phosphopantetheine and long acyl chain-dependent interactions are integral to human mitochondrial acyl carrier protein function 4'-Phosphopantetheine and long acyl … WebBinding to a protein. ... 4'-Phosphopantetheinyl transferases (PPTs) catalyze the transfer of 4'-phosphopantetheine (4-PP) from coenzyme A to a conserved serine residue of their protein substrates. In humans, the number of pathways utilizing the 4-PP post-translational modification is limited and may only require a single broad specificity PPT ...
Webprotein Summary Phosphopantetheine-binding protein (Streptomyces rimosus subsp. rimosus ATCC 10970) Cite Download Contents 1 Sequence 2 Interactions and Pathways 3 …
WebPlease help us improve further — take a moment to fill our brief user survey. chpg women\u0027s health avistaWebMay 30, 2024 · FIGURE 2.(A) Structural superposition of apo Mab PPAT in complex with feed-back inhibitor CoA (grey), PDB code 7YXZ and product dpCoA (green), PDB code 5O08, showing conformational differences in the enzyme and ligand binding mode.(B) The pantetheine moiety of CoA adopts a similar conformation to that of dpCoA. However, the … chpg women\u0027s health coloradoWebJan 3, 2024 · Using E. coli LipB as a prototype, we show that the enzyme mainly recognizes the 4’-phosphopantetheine tethered acyl-chain of its donor substrate, and weakly binds the apo-acyl carrier protein. It can accept octanoate-from its own ACP, noncognate ACPs, as well as C 8 -CoA. chpg west littleton primary care littleton coWebProtein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. UniRef. Sequence clusters. … chpg women\u0027s health littleton faxWebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins 138 – ‘acyl carrier proteins (ACPs) and peptidyl carrier proteins ... (for 4′-phosphopantetheine 10). The binding of dephospho-CoA was also shown to be competitive with both ATP and phosphopantetheine, whereas ... chpg women\u0027s health littletonWebThe acyl carrier protein ( ACP) is a cofactor of both fatty acid and polyketide biosynthesis machinery. It is one of the most abundant proteins in cells of E. coli. [1] In both cases, the … chpg women\u0027s health louisvilleWebphosphopantetheine-binding protein 61012291 - Gene ResultWI98_RS26710 phosphopantetheine-binding protein [] Gene provides a unified query environment for … chpg west littleton