Phenytoin as antiarrhythmic
WebUnlabeled Use: As an antiarrhythmic, particularly for ventricular arrhythmias associated with digoxin toxicity, prolonged QT interval, and surgical repair of congenital heart diseases in children. Management of neuropathic pain, including trigeminal neuralgia. Action Limits seizure propagation by altering ion transport. The Vaughan Williams classification was introduced in 1970 by Miles Vaughan Williams. Vaughan Williams was a pharmacology tutor at Hertford College, Oxford. One of his students, Bramah N. Singh, contributed to the development of the classification system. The system is therefore sometimes known as the Singh-Vaughan Williams classification. The five main classes in the Vaughan Williams classification of antiarrhythmic agents are:
Phenytoin as antiarrhythmic
Did you know?
WebPhenytoin inhibits the spread of spinal cord reflexes and has a stabilizing influence on peripheral nerves and heart muscle cells. For this reason, it is also used as an antiarrhythmic. Phenytoin is rapidly absorbed in the small intestine. Inactivation occurs via hydroxylation in the liver. The main metabolite is excreted through the kidneys. WebPhenytoin has a limited spectrum of antiarrhythmic activity. Its primary use is in management of digitalis-induced arrhythmias, because it abolishes digitalis-induced …
WebThe antiarrhythmic effects of procainamide and phenytoin were studied in 81 patients admitted to the coronary care unit at the University Hospital in Linköping because of a suspected or proven diagnosis of acute myocardial infarction, and who developed ventricular arrhyhmias, requiring treatment, during the first 8 hours in hospital. Patients … WebOct 13, 2024 · Class 1 antiarrhythmics bind to and block the fast Na channels in non-nodal tissue (e.g., myocytes of the atria and ventricles, His-Purkinje system): The slope of phase 0 depends on: Activation of fast Na …
WebMay 2, 2024 · Phenytoin is an anti-epileptic drug, also called an anticonvulsant. Phenytoin works by slowing down impulses in the brain that cause seizures. Phenytoin is used to … WebJan 15, 2024 · Phenytoin is a Vaughn Williams Class IB antiarrhythmic; although, it is almost never used as an antiarrhythmic anymore. Its effects on the cardiac voltage-gated sodium …
WebThe results of this investigation clearly demonstrate the overall superiority of procainamide over phenytoin as an antiarrhythmic drug in short-term therapy after acute myocardial …
WebFor the nine patients who had success with phenytoin the mean follow-up was 18.4 ± 11.7 months, and the 12-month actuarial recurrence was 0%. Phenytoin is a well tolerated drug whose efficacy appears similar to most standard antiarrhythmic agents. hemingways nairobi addressWebAntiarrhythmics are medications that prevent and treat a heart rhythm that is too fast or irregular also known as arrhythmias. Arrhythmia involves a problem with your heart’s … hemingways near meWebApr 18, 2024 · See the list below: Ia - Quinidine, procainamide, disopyramide (depress phase 0, prolonging repolarization) Ib - Lidocaine, phenytoin, mexiletine (depress phase 0 selectively in abnormal/ischemic... hemingway snows of kilimanjaroWebMar 18, 2024 · Antiarrhythmic drugs do not improve the survival of patients with non-life-threatening arrhythmias and may increase mortality, particularly in patients with structural … hemingways nashville menuWebJun 12, 2015 · Phenytoin's narrow therapeutic window, multiple drug interactions and side effect profile make it an infrequently used antiarrhythmic. It is, however, a potent antiarrhythmic agent, which may be useful in treatment of ventricular tachycardia, especially in patients with multiple drug intolerances. 2015 BMJ Publishing Group Ltd. Publication … hemingways newport riWebAug 5, 2013 · However, phenytoin has also been shown to have cardiac effects and is classified as a class 1b antiarrhythmic [4]. The most common presenting symptoms of phenytoin toxicity include unsteady gait ... hemingways nairobi limitedWebPhenytoin is an antiseizure drug that is occasionally used as an antiarrhythmic, specifically in digitalis overdose to reverse atrioventricular block. It is known to have many side … hemingways mara