WebNov 15, 2013 · Up to 60-80% of patients in this age group have hypertension (HTN) (Burt VL et al. Hypertension 1999), and are on anti-hypertensive medications. A standard … WebSep 1, 2016 · This long-term follow-up study aimed to assess the prognosis of systemic light chain amyloidosis (AL) patients treated with high-dose melphalan (HDM) chemotherapy and autologous stem cell transplantation, depending on iFISH results. Therefore, we analyzed a consecutive cohort of 123 AL patients recruited from 2003 to 2014.
High-dose melphalan with or without stem cell support …
WebAll study samples will be collected from participants while they are hospitalized to receive standard of care high-dose Melphalan (HDM) chemotherapy and autologous peripheral blood stem cell transplantation (ASCT). Patients who receive this treatment are typically admitted the day before HDM. WebNov 19, 2004 · The use of additional induction chemotherapy prior to HDM has been evaluated in a few studies to date (Sezer et al, 1999; van Gameren et al, 2002; Gono et al, 2003). New regimens, including induction chemotherapy prior to HDM need to be tested in order to assess whether the results of this regimen can be improved in terms of toxicity … thermos fashion
History of Changes for Study: NCT02589860 - ClinicalTrials.gov
WebHigh dose melphalan (HDM, 140 mg/m2 i.v.) has been evaluated in 58 patients under 63 years with multiple myeloma. Among previously untreated patients 11/41 (27%) entered a complete remission (CR: no measurable myeloma protein and a normal bone marrow) and 21 (51%) entered a partial remission (more than 50% reduction in myeloma protein and … WebUnlike standard chemotherapy, specific inhibitors produce multiple side effects. Answers. True. answer-incorrect. False. answer-correct _____ drugs are a type of specific inhibitor that target the production of specific proteins. These drugs act by binding with the specific mRNA molecule,blocking translation (protein production). WebHigh-dose melphalan chemotherapy and autologous peripheral blood stem cell transplantation has been shown to result in durable hematologic response and prolonged overall survival in systemic AL amyloidosis. In this retrospective study, we evaluated clinical and hematologic responses in 69 patients with predominant liver involvement who were … thermos fbb