WebMar 1, 2024 · Expression of viral immediate early (IE) genes required host cell factor-1 (HCF1, or HCFC1; 300019) to recruit LSD1 to viral immediate early promoters. Depletion of LSD1 or dose-dependent inhibition of LSD1 with monoamine oxidase inhibitors (MAOIs) resulted in accumulation of repressive chromatin and a block to viral gene expression. WebA missense mutation in a global transcriptional coregulator, HCFC1, was identified as the genetic basis of an X-linked form of combined methylmalonic acidemia and hyperhomocysteinemia. HCFC1 is a common component of active human CpG-island promoters and coincides with ZNF143, THAP11, YY1, and GABP transcription factor …
HCFC1 loss-of-function mutations disrupt neuronal and
Web(Mori et al., 2006). We compared the effects of tamoxifen treatment of GLAST-CreERT2 + ; Hcfc1 lox/Y and GLAST-CreERT2 -; Hcfc1 lox/Y mice at E16.5 on astroglia development. WebNov 5, 2024 · Even though only 8% of the decreased loop anchors in HCFC1 and ZNF143 double knockdown cells were HCFC1 and ZNF143 co-bound peaks (Supplementary Fig. 11e), HCFC1/ZNF143 motif was still one of the ... fight tampa bay and new orleans
Hcfc1a regulates neural precursor proliferation and
WebDec 1, 2014 · Mutations in HCFC1 (MIM300019), have been recently associated with cblX (MIM309541), an X-linked, recessive disorder characterized by multiple congenital anomalies including craniofacial abnormalities. HCFC1 is a transcriptional co-regulator that modulates the expression of numerous downstream targe … WebApr 1, 2016 · Prior to tamoxifen treatment, all Alb-Cre-ERT2 tg; Hcfc1 lox/+ hepatocytes and non-hepatocytes — identified as hepatocyte nuclear factor α (HNF4α)-positive (green arrows in Fig. 10 B) and -negative (mauve arrows) cells, respectively — are positive for HCF-1 (Fig. 10 A and B), indicating that the Cre-ERT2 recombinase activity is strongly ... WebThe HCFC1 protein is comprised of multiple domains that function in cellular proliferation/metabolism. Several reports of HCFC1 disease variants have been … grizzle gray sherwin-williams