Buthioninsulfoximin
Webbuthionine sulfoximine: A compound that inhibits gamma-glutamyl cysteine synthetase, which is required in the first step of glutathione synthesis; it is used in oncology to reduce … WebExperiments were carried out to investigate whether or not depletion of the glutathione (GSH) level in Drosophila melanogaster larvae with buthionine sulfoximine (BSO) …
Buthioninsulfoximin
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WebButhioninsulfoximin ist eine synthetisch erzeugte chemische Verbindung, die zu den Aminosäuren und Sulfoximinen zählt. BSO wirkt als Inhibitor der Glutamatcysteinligase und führt daher zu einem Absinken des Glutathionspiegels. Die Verbindung wird in der Forschung zur Erzeugung von oxidativem Stress eingesetzt[4] und kann auch als … WebButhionine sulfoximine C8H18N2O3S CID 21157 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and …
WebOxidative stress and genomic rearrangements play a role in cancer development. l-Buthionine-sulfoximine (BSO) induces oxidative stress in a cell by irreversibly inhibiting gamma-glutamylcysteine synthetase, an essential enzyme for the synthesis of glutathione (GSH). We postulated that oxidative stre … Webbuthionine sulfoximine: A compound that inhibits gamma-glutamyl cysteine synthetase, which is required in the first step of glutathione synthesis; it is used in oncology to reduce glutathione levels and in tropical medicine to increase the susceptibility of parasite to oxidative agents.
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WebFeb 8, 2024 · Consistently, Tsvetkov et al. showed that depletion of GSH by buthionine sulfoximine promotes copper-induced cell death . Interestingly, several studies have shown that p53 plays a role in GSH biogenesis. p53 was found to transcriptionally repress the expression of SLC7A11, which is critical for the import of the GSH precursor cystine ...
WebThe most widely used inhibitor has been buthionine sulfoximine (BSO), an analog of the glutamine synthetase (glutamate–ammonia ligase) inhibitor methionine sulfoximine. … pokemon vullaby evolutionWebAlteration of bleomycin cytotoxicity by glutathione depletion or elevation bank paninWeb508228 Sigma-Aldrich L- Buthionine Sulfoximine - CAS 83730-53-4 - Calbiochem. Download; Zoom More>> Less<< MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. SDS; References; Data Sheet; Primary Target: gamma-glutamylcysteine synthetase. bank panelsWebl-buthionine-sulfoximine, l-buthionine sulfoximine, 2s-2-amino-4-butylsulfonimidoyl butanoic acid, l-buthionine-s,r-sulfoximine, l-buthionine s,r-sulfoximine, l-bso, butanoic … bank panin adalahWebButhionine sulfoximine (BSO) is a sulfoximine derivative which reduces levels of glutathione and is being investigated as an adjunct with chemotherapy in the treatment of cancer. [1] The compound inhibits gamma-glutamylcysteine synthetase, the enzyme required in the … pokemon violetto lista pokedexWebAdministration of buthionine sulfoximine during hypoxic exposure significantly increased the number of apoptotic cells and hoesct positive cells in hippocampus compared to hypoxic group treated with vehicle only. Iswar Baitharu, Vishal Jain, … pokemon vs 1 billion lionsWebButhionine sulfoximine promotes methylglyoxal-induced apoptotic cell death and oxidative stress in endothelial cells. Biol. Pharm. Bull. 33(4), 556-560 (2010). 5. … bank pang thai drama